The Collaboration for Research Excellence in Africa
CORE Africa
"Strengthening Research Capacity in Africa"

'Strengthening Researchapacitypy in Africa'


Comparing treatment adherence and Quality of Life in patients with venous thromboembolism on Rivaroxaban versus vitamin K antagonists at Douala General Hospital

Jerry Brown Njoh Aseneh, Faculty of Health Sciences, University of Buea, Cameroon


Background: Oral Anticoagulation therapy has greatly improved the survival and quality of life in venous thromboembolism patients. However, this favorable outcome relies considerably on the patient¿s adherence to prescribed oral anticoagulants. 

Objective: To assess adherence and impact of choice of oral anticoagulant therapy on the quality of life (QoL) of patients with venous thromboembolism patients at the Douala General Hospital (DGH). 

Methods: This will be a comparative cross-sectional study carried out at the outpatient consultation of the Cardiology unit in the Douala General Hospital. Non-probability sampling will be done with a minimum sample size of 80 participants. Consenting participants will be administered a questionnaires comprising socio-demographic related section, the EuroQoL 5D 5L(EQ-5D 5L) for quality of life and the Morisky Medication Adherence Scale 8 (MMAS-8) for treatment adherence. Data collected will be stored in Microsoft Excel Sheets. Chi squared test, Wilcoxon test and Spearman will be used where appropriate. Data analyses will be done using SPSS version 23. 

Expected Results: This study will provide preliminary information on the complementary parameters of treatment adherence and quality of life in venous thromboembolism patients treated with either new oral anticoagulants or vitamin K antagonists in sub-Saharan Africa. 

Keywords: Venous thromboembolism, Quality of life, treatment adherence, oral anticoagulants, sub-Saharan Africa.

Author: Jerry Brown Njoh Aseneh
Study Country: Cameroon
Affiliated Institution: University of Buea
Study Type: M.D. Thesis
State Of Research: Data collection ongoing